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Antipsychotics in dementia: Best Practice Guide

 Introduction, Rationale and Key Points 
 Behavioural and Psychological Symptoms of Dementia (BPSD) 
 Assessment of patients with BPSD 
 Non-pharmacological treatment of BPSD 
 Pharmacological treatment of BPSD 
 Adverse effects of antipsychotics 
 Dementia with Lewy Bodies (DLB) 
 Other medicines for BPSD 
 Treatment of comorbid conditions in patients with dementia 
 References 
 Appendix 
  Click here for a PDF

References.

  1. Anon 2008 Always a Last Resort. All Party Parliamentary Group on Dementia, April 2008. Avaialble from: http://www.alzheimers.org.uk/downloads/ALZ_Society_APPG.pdf (accessed 07/08)
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  3. International Psychogeriatric Association. BPSD: Introduction to behavioural and psychological symptoms of dementia, 2002. http://www.ipa-online.org
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  11. Schneider LS et al. Efficacy and adverse effects of atypical antipsychotics for dementia: meta-analysis of randomized, placebo-controlled trials. Am J Geriatr Psychiatry 2006;14:191-210
  12. NPS (National Prescribing Service), 2007.. The role of antipsychotics in managing BPSD. Prescribing Practice Review 37. Available from; http://www.nps.org.au/ (accessed July 2008)
  13. NICE Dementia Guidelines 2006. Available from; http://www.nice.org.uk/cg42 (accessed July 2008)
  14. Ballard CG et al. A 3-month, randomized, placebo-controlled, neuroleptic discontinuation study in 100 people with dementia: the neuropsychiatric inventory median cutoff is a predictor of clinical outcome. J Clin Psychiatry 2004;65:114-9
  15. Fossey J et al. Effect of enhanced psychosocial care on antipsychotic use in nursing home residents with severe dementia: cluster randomised trial.BMJ 2006;332:756-61
  16. MEREC, 2007. The treatment of dementia. National Prescribing Centre (UK). Available from; http://www.npc.co.uk/ebt/merec/cns/dementia/merec_bulletin_vol18_no1_main.html (accessed July 2008)
  17. Schneider LS, Dagerman KS, Insel P. Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials. JAMA 2005;294:1934-43
  18. McKeith I et al. Dementia with Lewy bodies. Lancet Neurol 2004;3:19-28
  19. Glass J et al. Sedative hypnotics in older people with insomnia; meta-analysis of risks and benefits. BMJ 2005;331:1169
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