Investigating Thyroid Function
In patients with thyroid cancer, dosages of thyroxine that produce TSH suppression are intentionally used, because TSH is thought to promote tumour recurrence. TSH should be suppressed, but not to undetectable levels. Anti-thyroglobulin antibodies should also be measured to exclude interference with thyroglobulin assays. Thyroglobulin values below 2 ug/L, in the absence of thyroglobulin antibodies (particularly if TSH is elevated) are a useful negative predictor of residual or recurrent differentiated thyroid cancer.
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